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Hydrochlorothiazide is not effective in patients with CrCl <30 mL/min and thus, should not be given to patients with severe renal impairment or anuria. Getzar Plus is also contraindicated in patients with Addison's disease. Thiazide can reduce urinary excretion of calcium, sometimes resulting in mild hypercalcemia and is therefore contraindicated to patients with preexisting hypercalcemia.
Use in pregnancy & lactation: It is contraindicated in pregnancy since it has been associated with fetal toxicity in animal studies and other drugs eg, ACE inhibitors that act on the renin-angiotensin system have been associated with fetal toxicity in humans.
